ParkinsonCanadaV1, Main, Exploration, bibRecord, 000267

Nondopaminergic treatments for Parkinson's disease: current and future prospects.

Identifieur interne : 000267 ( Main/Exploration ); précédent : 000266; suivant : 000268

Nondopaminergic treatments for Parkinson's disease: current and future prospects.

Auteurs : Maria Eliza Freitas [Canada] ; Susan H. Fox [Canada]

Source :

Neurodegenerative disease management [ 1758-2032 ] ; 2016.

RBID : pubmed:27230697

Abstract

Parkinson's disease is primarily caused by dysfunction of dopaminergic neurons, however, nondopaminergic (ND) systems are also involved. ND targets are potentially useful to reduce doses of levodopa or to treat nonlevodopa-responsive symptoms. Recent studies have investigated the role of ND drugs for motor and nonmotor symptoms. Adenosine A2A receptor antagonists, mixed inhibitors of sodium/calcium channels and monoamine oxidase-B have recently been found to improve motor fluctuations. N-methyl-d-aspartate receptor antagonists and serotonin 5HT1B receptor agonists demonstrated benefit in levodopa-induced dyskinesia. Conversely, studies using antiepileptic drugs and adrenoreceptor antagonist had conflicting results. Moreover, metabotropic glutamate receptor antagonists also failed to improve symptoms. The current review summarizes the most recent findings on ND drugs over the last 2 years.

DOI: 10.2217/nmt-2016-0005
PubMed: 27230697

Affiliations:

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<front><div type="abstract" xml:lang="en">Parkinson's disease is primarily caused by dysfunction of dopaminergic neurons, however, nondopaminergic (ND) systems are also involved. ND targets are potentially useful to reduce doses of levodopa or to treat nonlevodopa-responsive symptoms. Recent studies have investigated the role of ND drugs for motor and nonmotor symptoms. Adenosine A2A receptor antagonists, mixed inhibitors of sodium/calcium channels and monoamine oxidase-B have recently been found to improve motor fluctuations. N-methyl-d-aspartate receptor antagonists and serotonin 5HT1B receptor agonists demonstrated benefit in levodopa-induced dyskinesia. Conversely, studies using antiepileptic drugs and adrenoreceptor antagonist had conflicting results. Moreover, metabotropic glutamate receptor antagonists also failed to improve symptoms. The current review summarizes the most recent findings on ND drugs over the last 2 years.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Nondopaminergic treatments for Parkinson's disease: current and future prospects.

Nondopaminergic treatments for Parkinson's disease: current and future prospects.

Source :

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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